Publications

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John Posner
BSc PhD MBBS FRCP FFPM

 

Books, Chapters and Invited Reviews

Posner J.  Pain models in healthy volunteers. The Role of Clinical Measurement in Evaluation of New Drugs.
Publ. Woolf Edinburgh. Ed. Nimmo WS & Tucker G 1991; Chapter 8: 73-90.

Cohen AF, Posner J (Editors).  A Guide to Clinical Research.
Publ. Kluwer Academic Publishers Inc. 2nd edition 2000 (1st edition 1995).

Posner J, Rolan PE.  The Textbook of Pharmaceutical Medicine.
Chapter 5: Clinical Pharmacokinetics
Publ. Ed. Griffin, O’Grady and Wells, 3rd edition 1998 and previous editions.

Posner J.  The Textbook of Pharmaceutical Medicine.
Chapter 4: Exploratory Development.
Publ. Blackwells.
Ed. Griffin, Publ. 6th edition 2009, and all previous editions.

Posner J.  The Textbook of Pharmaceutical Medicine.
Editor of 7th Edition with Griffin JP and G. Barker.
Publ. Wiley. Author of Chapter 4 and Chapter 7.  In Press.

Posner J.  Clinical Pharmacology: The Basics.  Surgery 2009; 27:153-157. 

Posner J.  Clinical Pharmacology: The Basics.  Surgery 2012; 4:174-180.

Editorials, Letters, Commentaries and Invited Reviews

Cohen AF, Posner J
Effects of 2 antihistamine drugs on actual driving performance.
Br Med J 1984; 288:935.

Posner J
Clinical pharmacology - mutual benefits from greater cooperation between academia and the pharmaceutical industry.
Br J Clin Pharmac 1991; 32:531-533.

Harry J, Baber N and Posner J
HIV screening in healthy volunteers.
Br J Clin Pharmac 1995; 39:213.

Posner J, Griffin JP. Commentary: Generic Prescribing. Br J Clin Pharmacol 2011; 72 (5):731-2.

Posner J. Commentary: Optimising the dose of dabigatran etexilate.  Br J Clin Pharmacol 2012; in press.  Published on line 7th June 2012.  DOI: 10.1111/j.1365-2125.2012.04353.x

Abstracts

Author of more than 50 peer-reviewed abstracts of oral and poster presentations mostly published in the British Journal of Clinical Pharmacology and numerous other posters presented at international conferences and symposia.

The most recent poster was presented at the American Society of Clinical Oncology June 2012 entitled: A phase 1 study of S-222611, an oral reversible dual inhibitor of EGFR and HER2, in patients with solid tumors. Baird R, Papa S, Cresti N, Hatcher H, Hogarth L Jamal-Hanjani M, Donaldson KM, Posner J, Kawabata I, Frenkel E, Jodrell D, Plummer R, Spicer J

Refereed Papers

1. Bennett A, Posner J
   Studies on prostaglandin antagonists
   Br J Pharmac 1971; 42:584-594.
   
   
2. Posner J
   Prostaglandin E2 and the bovine sphincter pupillae
   Br J Pharmac 1973; 49:415-427.
   
   
3. Larson E, Nicholson C, Loewi G, Posner J, Tyrrell DAJ
   Arthritis after meningococcal meningitis
   Br Med J 1977; 1:618
   
   
4. Berginer V, Posner J, Kahana E
   Multiple Sclerosis in Israeli Bedouin
   Israel J Med Sci 1982; 18:249-252.
   
   
5. Posner J, Ilya R, Wanderman K, Weitzmann S
   Systolic Time Intervals in Diabetes
   Diabetologia 1983; 24:249-252.
   
   
6. Weinhouse E, Kaplansky Y, Posner J
   Comparison of digoxin-induced cardiac toxicity in resistant and sensitive species
   J Pharm Pharmacol 1983; 35:580-583.
   
   
7. Posner J, Sobel RJ, Glick S
   Effects of amiodarone on thyroid hormone economy
   Israel J Med Sci 1984; 20:113-117.
   
   
8. Posner J
   A modified submaximal effort tourniquet test for evaluation of analgesics
   Pain 1984; 19:143-151.
   
   
9. Posner J, Bye A, Jeal S, Peck AW, Whiteman PD
   Alcohol and pharmacokinetics of bupropion in healthy volunteers
   Europ J Clin Pharmacol 1984; 26:627-630.
   
   
10. Cohen AF, Posner J, Ashby L, Smith R, Peck AW
    A comparison of methods of assessing the sedative effects of diphenhydramine on skills related to car driving
    Europ J Clin Pharmacol 1984; 27:471-475.
    
    
11. Whiteman PD, Bye A, Fowle ASE, Jeal S, Land G, Posner J
    Tolerance and pharmacokinetics of an acyclovir analogue A515U in man
    Europ J Clin Pharmacol 1984; 27:471-475.
    
    
12. Posner J, Telekes A, Crowley D, Phillipson R, Peck AW
    Effects of an opiate on cold-induced pain and the CNS in healthy volunteers
    Pain 1985; 23: 73-82.
    
    
13. Posner J, Bye A, Dean K, Peck AW, Whiteman PD
    The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses
    Europ J Clin Pharmacol 1985; 29: 97-103.
    
    
14. Posner J, Burke CA
    The effects of naloxone on opiate and placebo analgesia in healthy volunteers
    Psychopharmacol 1985; 87:468-473.
    
    
15. Findlay JWA, Fowle ASE, Butz RF, Jones EC, Weatherley BC, Welch RM, Posner J
    Comparative disposition of codeine and pholcodine in man after single oral doses
    Br J Clin Pharmac 1986; 22:61-71.
    
    
16. Posner J, Danhof M, Theunissen MWE, Breimer DD, Whiteman PD
    The disposition of antipyrine and its metabolites in young and elderly healthy volunteers
    Br J Clin Pharmac 1987; 24:51-55.
    
    
17. Posner J, Dean K, Jeal S, Moody SG, Peck AW, Rutter G, Telekes A.
    A preliminary study of the pharmacodynamincs and pharmacokinetics of a novel enkephalin analogue [Tyr.D.Arg-Gly-Phe(4NO2).Pro.NH2(BW443C)] in healthy volunteers.
    Europ J Clin Pharmacol 1988; 34:67-71.
    
    
18. Posner J, Cohen AF, Land G, Winton C, Peck AW
    The pharmacokinetics of lamotrigine (BW430C) in healthy subjects with unconjugated hyperbilirubinemia (Gilbert’s Syndrome)
    Br J Clin Pharmac 1989; 28:117-120.
    
    
19. Rolan PE, Adams J, Posner J
    Histamine bronchial challenge in volunteers
    J Int Med Res 1989; 17 (Suppl 2): 35-39B.
    
    
20. Posner J, Moody SG, Peck AW, Rutter D, Telekes A
    Analgesic, central, cardiovascular and endocrine effects of the enkephalin analogue Tyr-D.Arg-Cly-Phe(4NO2)-Pro-NH2 (443C81) in healthy volunteers
    Europ J Clin Pharmacol 1990; 38:213-218.
    
    
21. Rolan PE, Phillips S, Adams J, Posner J
    The onset of effect of the H1 -antagonist acrivastine (“Semprex”) assessed by histamine bronchial challenge in volunteers
    Europ J Clin Pharmacol 1990; 39:311-313.
    
    
22. Cohen AF, Harkin N, Posner J
    The cardiovascular effects of a novel enkephalin analogue, 443C81, in man.
    J Cardiovas Pharmacol 1990; 16:455-460.
    
    
23. Posner J, Holdich T, Crome P
    Comparison of lamotrigine pharmacokinetics in young and elderly healthy volunteers
    J Pharmaceut Med 1991;1: 121-128.
    
    
24. Chowdry NB, Gray SJ, Posner J, Fuller RW
    The effect of 443C81, a opioid receptor agonist, on the response to inhaled capsaicin in healthy volunteers.
    Br J Clin Pharmac 1991; 32: 633-636.
    
    
25. Gray SJ, Parker JE, Giles H, Bolofo M, Phillips S, Posner J
    The effects of a partial PGD2 agonist, 192C, on platelet aggregation and the cardiovascular system in healthy volunteers
    Br J Clin Pharmac 1992; 34:344-351.
    
    
26. Phillips SC, Rolan PE, Posner J, Malpern S, Wijayawardhana P, Crome P.
    Greater ease of swallowing of a new film coated 800 mg dispersible acyclovir (Zovirax) tablet compared to the standard 800 mg tablet in healthy elderly volunteers.
    J Pharm Med 1992; 2:259-262.
    
    
27. Rolan PE, Parker JE, Gray SJ, Weatherley BC, Ingram J, Leavens W, Wootton R, Posner J.
    The pharmacokinetics, tolerability and pharmacodynamics of tucaresol (589C80:4)[2-formyl-3-hydroxyphenoxymethyl], a potential anti-sickling agent, following oral administration to healthy subjects
    Br J Clin Pharmac 1993; 35:419-425.
    
    
28. Rolan PE, Mercer AJ, Weatherley BC, Holdich T, Meire H, Peck RW, Ridout G, Posner J
    Examination of some factors responsible for a food-induced increase in the absorption of atovaquone
    Br J Clin Pharmac 1994; 37:13-20.
    
    
29. Peck RW, Wootton R, Lee DR, Jackson SHD, Posner J
    The bioavailability and disposition of 1-ß-D-arabinofuranosyl)-5-(1-propynyl)uracil (882C87), a potent, new anti-varicella zoser virus agent
    Br J Clin Pharmac 1995; 39:143-149.
    
    
30. Peck RW, Weatherley BC, Wootton R, Crome P, Holdich TA, Posner J
    Pharmacokinetics and tolerability of single oral doses of 882C87, a potent new anti-varicella zoster virus agent, in healthy volunteers
    Antimicrobial Agents and Chemotherapy 1995; 39:20-27.
    
    
31. Rolan PE, Mercer A, Wootton R, Posner J
    Pharmacokinetics and pharmacodynamics of tucaresol, an antisickling agent, in healthy volunteers
    Br J Clin Pharmac 1995; 39:375-380.
    
    
32. Soul-Lawton J, Seaber E, On N, Wootton R, Rolan P, Posner J
    Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans
    Antimicrobial agents and Chemotherapy 1995; 39:2759-2764.
    
    
33. Peck R, Wiggs R, Posner J
    The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA:Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability in healthy volunteers
    Europ J Clin Pharmacol. 1995; 49:243-249.
    
    
34. Mercer A, Hussein Z, Lamb R, Hobbiger S, Posner J
    The pharmacokinetics and pharmacodynamics of increasing intravenous doses of 619C89, a novel compound for the acute treatment of stroke, in healthy volunteers
    Ann NY Acad Sci. 1995; 765:324-327.
    
    
35. Peck RW, Wiggs R, Callaghan J, Wootton R, Crome P, Fraser I, Frick L, Posner J
    Inhibition of dihydropyrimidine dehydrogenase by 5-propynyluracil, a metabolite of the antivaricella zoster virus agent, netivudine.
    Clin Pharmacol Therap 1996; 59: 22-31.
    
    
36. Seaber E, On N, Phillips S, Churchus R, Posner J, Rolan PE
    The tolerability and pharmacokinetics of the novel antimigraine compound 311C90 in healthy male volunteers
    Br J Clin Pharmac 1996; 41:141-148.
    
    
37. De Bony F, Bidault R, Peck R, Posner J
    Lack of interaction between valaciclovir, the L-valyl ester of acyclovir, and Maalox antacid
    J Antimicrob Chemotherap 1996; 37:383-387.
    
    
38. Fillastre JP, Godin M, Legallicier B, Chretien P, Bidault R, Gilotin C, Wootton R, Posner J, Peck RW
    Pharmacokinetics of netivudine, a potent antivaricella zoster virus drug, in patients with renal impairment
    J Antimicrob Chemotherap 1996; 37:965-974.
    
    
39. Le Roy F,, Godin M, Legallicler B, Fillastre JP, Bidault R, Posner J, Peck RW
    Pharmacokinetics of netivudine in haemodialysis patients
    J Antimicrob Chemotherap 1996;38:913-915.
    
    
40. Hussein Z, Fraser IJ, Lees KR, Muir KW, Lunnon MW, Hobbiger SF, Posner J
    Pharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions
    Br J Clin Pharmac 1996; 41:505-513.
    
    
41. Arya R, Rolan PE, Wootton R, Posner J, Bellingham AJ
    Tucaresol increases oxygen affinity and reduces hemolysis in subjects with sickle cell anaemia
    Br J Haematol 1996; 93:817-821.
    
    
42. Davis JD, Dixon R, Khan AZ, Toon S, Rolan PE, Posner J
    Atovaquone has no effect on the pharmacokinetics of phenytoin in healthy male volunteers
    Br J Clin Pharmac 1996; 42:246-248.
    
    
43. Dixon R, Pozniak AL, Watt HM, Rolan P, Posner J
    Single-dose and steady-state pharmacokinetics of a novel microfluidized suspension of atovaquone in human immunodeficiency virus-seropositive patients
    Antimicrob Agents Chemother 1996; 40:556-560.
    
    
44. Wootton R, Soul-Lawton J, Rolan PE, Fook Sheung CTC, Cooper JDH, Posner J
    Comparison of the pharmacokinetics of lamotrigine in patients with chronic renal failure and healthy volunteers
    Br J Clin Pharmac 1997; 43:23-27.
    
    
45. Hussein Z, Posner J
    Population pharmacokinetics of lamotrigine monotherapy in patients with epilepsy: a retrospective analysis of routine monitoring data
    Br J Clin Pharmac 1997; 43:457-465.
    
    
46. Dixon R, Gillotin C, Gibbens M, Posner J, Peck RW
    The pharmacokinetics and effects on blood pressure of multiple doses of the novel anti-migraine drug zolmitriptan (311C90) in healthy volunteers
    Br J Clin Pharmac 1997; 43:273-281.
    
    
47. Seaber E, On N, Dixon RM, Gibbens M, Leavens WJ, Liptrot J, Chittick G, Posner J, Rolan PE,
    Peck RW
    The absolute bioavailability and metabolic disposition of the novel antimigraine compound zolmitriptan (311C90)
    Br J Clin Pharmac 1997; 43:579-587.
    
    
48. Dixon RM, Meire HB, Posner J, Rolan PE
    Evaluation of non-invasive techniques to assess vasoconstriction in healthy volunteers using methoxamine as a probe drug
    Cephalalgia 1997; 17:639-646.
    
    
49. Rolan PE, Mercer AJ, Tate E, Benjamin I, Posner J
    Disposition of atovaquone in humans
    Antimicrob Agents Chemother 1997; 41:1319-1321.
    
    
50. Seaber EJ, Ridout G, Layton G, Posner J, Peck RW
    The novel anti-migraine compound zolmitriptan (Zomig 311C90) has not clinically significant interactions with paraetamol or metoclopramide
    Eur J Clin Pharmacol 1997; 53:229-234.
    
    
51. Peck RW, Seaber EJ, Dixon R, Gillotin CG, Weatherley BC, Layton G, Posner J
    The interaction between propranolol and the novel antimigraine agent zolmitriptan (311C90).
    Br J Clin Pharmac 1997; 44:595-599.
    
    
52. Dixon, RM, Meire HB, Evans DH, Watt H, On N, Posner J, Rolan PE
    Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with ergotamine in healthy volunteers
    Cephalgia 1997; 17:639-646.
    
    
53. Peck RW, Seaber EJ, Dixon RM, Layton GR, Weatherley BC, Jackson SHD, Rolan PE, Posner J
    The pharmacodynamics and pharmacokinetics of the 5HTiB/D - agonist zolmitriptan in healthy young and elderly men and women
    Clin Pharmacol Ther 1998; 63:342-353.
    
    
54. Soul-Lawton JH, Weatherley BC, Posner J, Layton G, Peck RW
    Lack of interaction between valaciclovir, the L-valyl ester of aciclovir and digoxin
    Br J Clin Pharmacol 1998; 45:87-89.
    
    
55. Mercer AJ, Lamb RJ, Rolan, PE, Gibbens M, Posner J
    Lack of an effect of zolmitriptan (Zomig, 311C90), on psychometric task performance: results of a placebo controlled study in healthy volunteers
    Psychopharmacology 1998; 140:398-404.
    
    
56. Peck RW, Wooton R, Wiggs R, Layton G, Posner J
    Effect of food and gender on the pharmacokinetics of tucaresol in healthy volunteers
    Br J Clin Pharmac 1998; 46:83-86.
    
    
57. Klamt JG, Posner J
    Effects of lamotrigine on pain-induced chemo-somatosensory evoked potentials
    Anaesthesia 1999; 54:774-777.
    
    
58. De Bony F, Tod M, Bidault R, On NT, Posner J, Rolan P
    Multiple interactions of cimetidine and probenecid with valaciclovir and its metabolite acyclovir
    Antimicrob Agents Chemother 2002; 46:458-63.
    
    
59. Calder N, Boyce M, Posner J, Sciberras D. 
    Clinical pharmacology studies in UK Phase I units: an AHPPI survey 1999-2000. 
    Br J Clin Pharmac 2004; 57:76-79.
    
    
60. Rave, K, Nosek L, Posner J, Heise T, Roggen K, Hoogdalem EJ. 
    Renal glucose excretion as a function of blood glucose concentration in subjects with type 2 diabetes-results of a hyperglycaemic glucose clamp study. 
    Nephrol Dial Transplant. 2006; 21:2166-71.