Clinical Pharmacology II
Have extensive experience of numerous MODELS and METHODOLOGIES in healthy volunteers and patients including:
- Computerised test batteries for psychometric and cognitive function
- Tests of psychomotor function such as saccadic and smooth pursuit eye movements and adaptive tracking
- Various models for testing analgesia including cold and ischaemic pain
- Non-invasive cardiovascular measurements including forearm plethysmography, systolic time intervals, ultrasound, thoracic impedance
- Gastrointestinal transit and gastric pH monitoring
- Respiratory function tests such as whole body plethysmography, flow volume loops and spirometry with bronchial challenge using various agents
- Measurement of cough using various stimuli
- Skin wheals and flares and bronchial provocation for antihistamininic activity
- Hyperinsulinaemic euglycaemic clamps and other tests of glucose homeostasis
- Measurement of many other biomarkers such as platelet aggregometry, lipoxygenase activity, ACE activity